With ADR enabled it may vary. On the Conduit when a packet is queued for Class A it does not know what the datarate of the next uplink will be.
In US915 53 bytes is the allowed packet length for downlink in Rx1 when DR0 is used in the uplink.
Rx2 can be set to DR10 for most use cases and 242 bytes of application payload are allowed. The GW can transmit at a higher power than end-devices so it can reach end-devices easier with higher datarates. Performance may vary per environment of deployment.
The size will depend on the downlink datarates configured for Rx1 and Rx2. Rx1 is dependent on the uplink DR used and the Rx1Offset setting.
https://lora-alliance.org/resource-hub/rp2-102-lorawan-regional-parameters
The N column on page 34 shows the maximum size for each datarate.